Associate Professor of Radiology at Thomas Jefferson University and academic neuroradiologist focused on blood–brain barrier disruption, glymphatic dysfunction, neuroinflammation, neurovascular dysfunction, and advanced neuro-oncology MRI.
Dr. Chaganti is an academic neuroradiologist and translational neuroimaging investigator whose work integrates perfusion, permeability, diffusion, spectroscopy, functional connectivity, and emerging metabolic imaging methods to identify clinically meaningful imaging biomarkers in complex neurological disease.
Associate Professor of Radiology, Thomas Jefferson University, Philadelphia.
Attending Neuroradiologist, Jefferson Health.
Director of Vessel Wall Imaging, Thomas Jefferson University.
PhD, University of New South Wales, focused on advanced imaging biomarkers of HIV-associated neurocognitive impairment and neuroinflammation.
FRANZCR, DNB Radiology, MD Radiology, and MBBS.
Quantitative DCE-MRI, diffusion-prepared ASL, and functional MRI approaches to study BBB permeability, neurovascular unit dysfunction, and network-level brain injury.
Investigation of paravascular clearance, DTI-ALPS, perivascular-space imaging, and glymphatic–BBB coupling in Long COVID, hepatic encephalopathy, gliomas, and neuroinflammatory disease.
Integration of DCE, DSC, APT/CEST, ASL, diffusion imaging, spectroscopy, and functional MRI for tumor biology, glioma grading, recurrence, pseudoprogression, and radiation necrosis.
Demonstrated that BBB dysfunction persists in virally suppressed HAND and can be detected using DCE-MRI, supporting a mechanistic model of ongoing CNS neuroinflammation despite systemic virologic control.
Developed a multimodal MRI framework linking BBB permeability, glutamatergic abnormalities, and white matter injury in post-acute sequelae of SARS-CoV-2 infection.
Advanced a dual-hit model in which BBB permeability and impaired glymphatic clearance interact to disturb brain homeostasis and contribute to neurocognitive impairment.
Linked BBB permeability to disrupted functional connectivity and regional homogeneity, providing a mechanistic bridge between neurovascular injury and cognitive dysfunction.
Dr. Chaganti mentors residents, fellows, research assistants, and medical students in advanced MRI biomarker research, imaging interpretation, manuscript development, and academic presentation.
Daily case-based neuroradiology teaching and recurring didactic sessions.
Mentorship in DTI-ALPS, post-treatment tumor imaging, hepatic encephalopathy, demyelination, IIH, and ALSP.
Support for abstract preparation, manuscript writing, grant development, and journal submission strategy.
Clinical and translational work includes implementation of vessel wall imaging, DCE perfusion imaging, targeted perfusion analysis with hotspot interrogation, and emerging APT and ASL applications in glioma and dementia imaging.
For research collaboration, invited lectures, editorial work, or academic mentorship.
Department of Radiology
Thomas Jefferson University / Jefferson Health
Philadelphia, Pennsylvania